Grape Seed Extract

Why is Grape Seed Extract in my Dog’s Joint Supplement?

In a word… Antioxidants!

Grape seed extract contains chemicals known as procyothianids, which are naturally occurring chemicals that are present in the seeds of many fruits and vegetables. These chemicals are incredibly good antioxidants. These extracts are easily obtained, do not impart a bad flavor to the food or nutritional supplement, and are easily assimilated by the body of the canine. The anti-oxidative nature of these products is held in the cyanide containing part of the procyothianids which contain the carbon-nitrogen triple bond. This triple bond is incredibly antioxidative, and therefore very beneficial.
 
Grape Seed Extract Relieves Joint Disease in Dogs

Grape Seed Extract produce these procyothianids that scour the body looking for free radicals. Free radicals are chemicals that are erroneously created because of poor blood supply, lack of oxygen, and oxidative stress. These events occur following injury to the spinal cord, and are known to compromise blood supply due to other injuries in the extremities and other tissues.

Free radicals floating in the body also predispose the incorrect transcription and replication of DNA thereby producing mutations.

More importantly, free radicals are particularly responsible for the creation of tumors and or cancer. This is while most all nutritional supplements carry some degree of antioxidants. Antioxidants available in grape seed extract are not only inexpensive, well-tolerated, but are particularly effective.

It would be a mistake not to put grape seed extract into any nutritional supplement for dogs.

 
Why We Put Grape Seed Extract in Our Canine Joint Supplements

You will see below that we have created the formulation for a joint-directed supplement for dogs. In formulating this product, an antioxidant such as grape seed extract was necessary.

We’ve seen, over the last 35 years, that injury (either symptomatic or radiologic), or injury not showing symptoms or radiographic evidence, will compromise the nerve supply in the spinal cord, thereby compromising the nerve supply to the various organs and muscles, thereby compromising the blood supply to those organs and tissues that degrade chronically over time.

It can be said that the oxidative stress incurred in normal living will eventually compromise the blood supply to various organ systems and progress to rapid aging and death.

Rapid aging will, of course, shorten the lifespan of our beloved pets. However, this can be avoided for the most part by making sure that oxidative stress and other injurious phenomena and are either repaired or minimized. Unlike the other components of the joint formula that we created, grape seed extract affects the whole body because the whole body is subject to oxidative stress and free radical generation.

Grape seed extract then acts as a free radical scavenger of the oxidative stress byproducts of metabolism that shouldn’t be swirling around in the body.

Our product optimizes the very best of joint directed ingredients in a synergistic combination that repairs, rehabilitates, and protects the joints of the canine.

 
Why Are the Joints of the Spine so Important for a Joint Supplement?

The most important joints of the body are actually in the spine. It is those joints that develop degenerative osteoarthritic changes that, in turn, accelerate disease processes like degenerative myelopathy, degenerative disc disease, rapid aging, liver and kidney failure.

Acute and chronic problems should be treated by a veterinarian. However, these animals, whether they have acute or chronic debilitating injury, should also be placed on a joint directed supplement as part of their initial therapy and also as part of a continual plan to optimize joint health into their senior years.

It is our hope that this will help dogs live to be 14 to 17 years, instead of running out of gas at 10 to 12 years of age.

 
References

1. Carcinogenesis, Vol. 20, No. 9, 1737-1745, September 1999 Anti-tumor-promoting activity of a polyphenolic fraction isolated from grape seeds in the mouse skin two-stage initiation–promotion protocol and identification of procyanidin B5-3′-gallate as the most effective antioxidant constituent. Jifu Zhao, Jiannong Wang, Yingjie Chen and Rajesh Agarwal

2. Flavonoids (isoflavonoids and neoflavonoids). IUPAC Compendium of Chemical Terminology

3/ Ector BJ, Magee JB, Hegwood CP, Coign MJ., Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines.

4. University of Scranton at http://www.sdearthtimes.com/et0301/et0301s24.html

5. Resveratrol Concentration in Muscadine Berries, Juice, Pomace, Purees, Seeds, and Wines. B. J. Ector, J. B. Magee , C. P. Hegwood, and M. J. Coign Am. J. Enol. Vitic. 47:1:57-62 (1996)

6. Winter 2000/2001 issue of the Journal of Medicinal Food.

7. Polyphenolics in Grape Seeds – Biochemistry and Functionality. J-Med-Food 2003 Winter; 6(4):291-9 Shi-J, Yu-J, Pohorly-J-E, Kakuda-Y.

8. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, {Clin-Cancer-Res}, 15 Oct 2006, vol. 12, no. 20 Pt 1, p. 6194-202 Kaur-Manjinder, Singh-Rana-P, Gu-Mallikarjuna, Agarwal-Rajesh, Agarwal-Chapla.

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